{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

MCB 102 F08 Lect _10 DRAFT

MCB 102 F08 Lect _10 DRAFT - Announcements Adjustment to...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Announcements Adjustment to Lecture Schedule and Material: We will not formally cover anything more about antibodies (other than the ELISA assays we already discussed) and you will not be responsible for any of the material in Chapter 5 of your textbook on antibodies (or on actin and myosin) Hand-outs on : (a) A Primer of Enzyme Nomenclature (b) Derivation of the Michaelis-Menten Equation now available in the "Resources" section of MCB 102 F08 bSpace site.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Hemoglobin is an Allosteric Protein Response O 2 Positive homotropic effector BPG Negative heterotropic effector H + Negative heterotropic effector CO 2 Negative heterotropic effector Ligand
Background image of page 2
The cooperative properties of hemoglobin require continuous generation of the glycolytic intermediate, 2,3- bis -phoshoglycerate (BPG) BPG stabilizes the T state
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
H + and CO 2 promote oxygen release from hemoglobin: The Bohr Effect This salt bridge requires protonation of His146 and stabilizes the T state
Background image of page 4
carbonic anhydrase carbonic acid bicarbonate anion
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
OH - : H OH - bicarbonate carbamylated N-terminus Creates a new charged group that forms another salt bridge that stabilizes the T state Explaining the Bohr Effect. Part II
Background image of page 6
In addition to O 2 delivery, hemoglobin must also be considered a carrier of CO 2 and H +
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Enzymes are catalysts Catalysts promote chemical reactions Catalysts are not consumed or used up Catalysts are restored after reaction and can be re-used repeatedly
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}