MCB 102 F08 Lect _10 DRAFT

MCB 102 F08 Lect _10 DRAFT - Announcements Adjustment to...

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Announcements Adjustment to Lecture Schedule and Material: We will not formally cover anything more about antibodies (other than the ELISA assays we already discussed) and you will not be responsible for any of the material in Chapter 5 of your textbook on antibodies (or on actin and myosin) Hand-outs on : (a) A Primer of Enzyme Nomenclature (b) Derivation of the Michaelis-Menten Equation now available in the "Resources" section of MCB 102 F08 bSpace site.
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Hemoglobin is an Allosteric Protein Response O 2 Positive homotropic effector BPG Negative heterotropic effector H + Negative heterotropic effector CO 2 Negative heterotropic effector Ligand
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The cooperative properties of hemoglobin require continuous generation of the glycolytic intermediate, 2,3- bis -phoshoglycerate (BPG) BPG stabilizes the T state
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H + and CO 2 promote oxygen release from hemoglobin: The Bohr Effect This salt bridge requires protonation of His146 and stabilizes the T state
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carbonic anhydrase carbonic acid bicarbonate anion
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OH - : H OH - bicarbonate carbamylated N-terminus Creates a new charged group that forms another salt bridge that stabilizes the T state Explaining the Bohr Effect. Part II
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In addition to O 2 delivery, hemoglobin must also be considered a carrier of CO 2 and H +
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This note was uploaded on 02/22/2010 for the course MCB N/A taught by Professor Calendar,thorner during the Fall '08 term at University of California, Berkeley.

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MCB 102 F08 Lect _10 DRAFT - Announcements Adjustment to...

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