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MCB 102 F08 Lect _12 DRAFT

MCB 102 F08 Lect _12 DRAFT - Announcements EXAM#1 nd...

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Announcements EXAM #1 : THURSDAY EVENING, OCTOBER 2 nd 6:00-8:30 PM in 100 GPB (ADAMSON - DAO) in 150 Wheeler (DASGUPTA - ZHUANG) Review Session for Exam #1 : 5-7 PM, Room 10, Evans Hall, Wednesday evening, Oct. 1 st PRACTICE EXAM #1 : now posted on MCB 102 F08 bSpace site ANSWER KEY will be posted on Mon., 29 Sept.
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Enzyme inhibitors are valuable in medicine, public health, industry, and agriculture Two general classes of enzyme inhibitors: Reversible (do not covalently react with enzyme) Irreversible (covalently react with enzyme and permanently disable it)
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Irreversible inhibitors include: •Group-specific reagents Domestic terrorism in Japan: Kasumigaseki Station, one of the many affected by the Sarin gas attack on the Tokyo subway system on 20 March 1995 2-(Fluoro-methylphosphoryl)oxypropane
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Irreversible inhibitors include: •Reactive substrate analogs ("affinity labels") -
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Irreversible inhibitors include: •Suicide (mechanism-based) inhibitors Reaction catalyzed by ornithine decarboxylase Difluoromethylornithine is a mechanism-based inhibitor of ODCase that causes the enzyme to commit "suicide"
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Four Classes of Reversible Inhibitors A competitive inhibitor binds to the active site and prevents the substrate from binding
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