MCB 102 F08 Lect _13 DRAFT

MCB 102 F08 Lect _13 DRAFT - Control of protein lifetime...

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Announcements EXAM #1 : THURSDAY EVENING, OCTOBER 2 nd 6:00-8:30 PM in 100 GPB (ADAMSON - DAO) in 150 Wheeler (DASGUPTA - ZHUANG) Review Session for Exam #1 : 5-7 PM, Room 10, Evans Hall, Wednesday evening, Oct. 1 st
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Modes of Enzyme Regulation • Feedback control of allosteric enzymes (which catalyze the reaction at the first step, at a branch point, or as the pacemaker step of a metabolic pathway) by small-molecule effectors • Tissue- and compartment-specific isozymes and/or substrate sequestration • Modulation of subcellular localization and/or binding partners • Reversible covalent modifications (especially phosphorylation and dephosphorylation) • Proteolytic activation of zymogens
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Unformatted text preview: Control of protein lifetime Transcriptional regulation of the gene encoding the enzyme B C D E (Methionine-repressible)- plus Isoleucine-sensitive Regulatory domain Homoserine dehydrogenase domain Aspartate Transcarbamoylase End-product inhibition ATP "K" Allosteric Enzyme "V" Allosteric Enzyme SIDE VIEW TOP VIEW ATCase is a (C 3 ) 2 (R 2 ) 3 hetero-dodecamer TOP VIEW Asp Carbamyl-P ATCase C5 R1 + CTP + ATP + Asp O-OH Pr- Pr Reaction catalyzed by a Protein Kinase 1 Thr Thr Tyr Wee1 Cdc25 Role of Reversible Protein Phosphorylation in Enzyme Regulation Zymogen Activation Inside the cell Outside the cell...
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MCB 102 F08 Lect _13 DRAFT - Control of protein lifetime...

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