353_Lecture7_020310 - TransportPhenomenain LivingSystems...

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Transport Phenomena in  Living Systems  BME 353 Spring 2010 Lecture 7 February 3, 2010
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Blood exhibits a yield  stress obeys Casson constitutive relationship Behaves like a solid for  τ  <  τ y Behaves like a liquid for  τ     τ y
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Blood behaves like a Casson material (has a yield stress) at shear rates < 36 sec -1 , a Pseudoplastic (nonlinear) at intermediate shear rates and a Newtonian fluid at shear rates > 50 sec -1 . (Shear stress) 1/2 (Shear rate) 1/2 √τ y
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Yield Stress of Blood Increases with Fibrinogen Content Yield Stress τ y , (dynes/cm 2 ) 0 0.01 0.02 0.03 0.04 0 0.1 0.2 0.3 Fibrinogen Conc., (g/100 ml)
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Are homogeneous models  (Newtonian, Casson) valid for  computing flow resistance to  blood in  microvessels ?
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Rheology of the Microcirculation
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Fahraeus-Lindqvist Effect Am J Physiol 263:H1770-1778, 1992 H = 45 What is responsible for this observation? D = 7
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353_Lecture7_020310 - TransportPhenomenain LivingSystems...

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