Given kuru’s relation to bovine spongiform encephalopathy (BSE aka mad cow disease) has an association, is it possible to associate the PRNP polymorphism with agriculture rather than Neolithic endo-cannibalism? Consider the selection involved with that the rapid spread of disease promoting cultural change (as described Papua New Guinea, not mention applicability to the sickle-cell to malaria relationship) and pandemic cannibalism under this framework- such as the dimorphic adaptations radiating from Japan versus Europe/Africa (interposed by the Indian subcontinent and specifically Hinduism’s relationship with the cow, burning their dead, etc with that culture tracing back to the Harappan period, 7,000 BP). My point being I rather see Creutzfeldt-Jakob disease examined in terms of its own evolution (and diversity of its populations) rather than just looking at the prevalence of susceptibility amongst its hosts.
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Bovine spongiform encephalopathy, Papua New Guinea, New Guinea, Prion, Transmissible spongiform encephalopathy