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BIO 265 Section 7.3: Study Guide Section 7.3 Objectives: Describe how clearance is related to kidney function. Explain how the kidney concentrates and dilutes urine. 7.3 PHYSIOLOGY OF URINE PRODUCTION 7.3.1 - Renal Clearance Describe how clearance is related to kidney function. What is Renal Clearance and how is Renal Clearance calculated? o What does the symbol Cx stand for? o Ux? o Px? How do doctors test kidney clearance? Explain the only circumstances in which the clearance value is equal to the GFR and why that is. What is Creatine and what is the average value of Creatine Clearance? Explain how comparing the clearance value of a substance to the average value for creatinine clearance indicates if a substance is being reabsorbed or secreted by the kidney. o How does the kidney normally clear the following substances? Glucose: Inulin: PAH: Penicillin: o Explain what the following chart is illustrating: (Tip: Recall from section 2.2 the role of the N+/K+ ATPase transport pumps in reabsorption and what happens if they are over saturated.) Page 1
BIO 265 For more information, see these Video Resources: o Basic Renal Function: Clearance and GFR by Dr. Miller o Clearance of Wastes in Kidney – The Math by Macrophage Introducing Clearance: ? v=KGMOEo5iaG8&index=4&list=PLnab4uUuCkvJ7uzBz2xxxNq_sjZkQQ gcr Calculating Clearance: Measuring Clearance: Inulin and PAH: o The Nephron in Numbers: Renal Clearance by UofLPhysio:

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