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Unformatted text preview: BIOLOGY 315H From mutation to phenotype November 10, 2006 Today we will integrate some of the concepts we have gleaned from both genetics and cell biology. For example, the simple rules of Mendelian genetics indicate that some alleles are recessive to others at a given genetic locus. But how does the dominant/recessive relationship arise at the molecular level of the gene products? In discussing the relationship between genotype and phenotype, molecular geneticists steer away from terms like dominant and recessive which are used to describe patterns of inheritance, and instead classify genetic mutations according to their effect on gene function, e.g . loss-of-function (eliminates function of the gene product; amorphic or null alleles have a complete loss, hypomorphic alleles have reduced function) or gain-of-function (gene product has a new function or is produced under new...
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This note was uploaded on 02/22/2010 for the course BIO 51980 taught by Professor Buskirk during the Fall '06 term at University of Texas at Austin.
- Fall '06