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oct 2 - Poly-A tail is added to 3 end of eukaryotic mRNA In...

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1 In eukaryotes, RNA is processed after transcription A 5 methylated cap and a 3 Poly-A tail are added Structure of the methylated cap Poly-A tail is added to 3 end of eukaryotic mRNA RNA splicing removes introns Exons – sequences found in a gene s DNA and mature mRNA (expressed regions) Introns – sequences found in DNA but not in mRNA (intervening regions) Some eukaryotic genes have many introns Dystrophin gene underlying Duchenne muscular dystrophy (DMD) is an extreme example of introns Self-splicing introns Auto-catalytic RNAs How RNA processing splices out introns and adjoins adjacent exons
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2 Splicing is catalyzed by spliceosomes – Ribozymes – RNA molecules that act as enzymes – Ensures that all splicing reactions take place in concert Alternative splicing –Different mRNAs can be produced by the same transcript –Rare transplicing events combine exons from different genes Landmarks in a collagen gene of C. elegans and comparison of DNA and mRNA sequences tRNA is processed Translation Gene Expression The Flow of Genetic Information from DNA via RNA to Protein
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