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Unformatted text preview: Fig. 7.6 2 Xeroderma pigmentosum Defective excision repair 7 repair genes identied: XPA - XPG XPA: open complex formation XPB and XPD assist in open complex XPC is involved in sensing damage XPG and XPF function as endo nucleases Polymerase lls in the gap Other DNA repair defect diseases Ataxia telangiectasia- mismatch repair Fanconi anemia- at least 7 genes Cockayne syndrome- transcription coupled repair, 2 genes that encode for proteins that interact with transcription machinery and DNA repair protein These are autosomal recessive diseases...
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This note was uploaded on 02/22/2010 for the course BIO 51980 taught by Professor Buskirk during the Fall '06 term at University of Texas at Austin.
- Fall '06