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Unformatted text preview: Fig. 7.6 2 Xeroderma pigmentosum Defective excision repair 7 repair genes identiﬁed: XPA - XPG XPA: open complex formation XPB and XPD assist in open complex XPC is involved in sensing damage XPG and XPF function as endo nucleases Polymerase ﬁlls in the gap Other DNA repair defect diseases • Ataxia telangiectasia- mismatch repair • Fanconi anemia- at least 7 genes • Cockayne syndrome- transcription coupled repair, 2 genes that encode for proteins that interact with transcription machinery and DNA repair protein • These are autosomal recessive diseases...
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- Fall '06
- DNA, DNA repair, Xeroderma pigmentosum, Cockayne Syndrome, fanconi anemia, Ataxia telangiectasia