sept 27 - • Two a-helical regions separated by a turn in...

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Transcription 19/27/06 Major ideas and goals: 1. The initial step in accessing the information in the DNA is the transcription of the information into an RNA product or intermediate. 2. DNA not only encodes the information for the RNA and protein products but also contains information for the initiation, termination and regulation of transcription. 3. Proteins interact with DNA to regulate transcription and control the amount of RNA, and ultimately the amount of protein, produced. 4. You should be able to describe the common and unique features of prokaryotic and eukaryotic transcription.
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1 Initiation of transcription Elongation Termination Many DNA-Binding proteins contain a helix-turn-helix motif
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Unformatted text preview: • Two a-helical regions separated by a turn in the protein structure • Helix-turn-helix motif f ts into major groove of DNA • Most repressor proteins A positive regulator increases transcription of genes • AraC is a positive regulator for all arabinose genes which break down sugar arabinose • Loss of function mutation results in little or no expression of genes 2 In eukaryotes, RNA is processed after transcription • A 5 ± methylated cap and a 3 ± Poly-A tail are added • Structure of the methylated cap Poly-A tail is added to 3 ± end of eukaryotic mRNA Poly-A tail is added to 3 ± end of eukaryotic mRNA...
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This note was uploaded on 02/22/2010 for the course BIO 51980 taught by Professor Buskirk during the Fall '06 term at University of Texas.

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sept 27 - • Two a-helical regions separated by a turn in...

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