Chem 243b - Heme Analog

Chem 243b - Heme Analog - 5B: Macrocyclic Synthesis (Heme...

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5B: Macrocyclic Synthesis (Heme Analog) Antonio Alarcon Chem 243B 2/23/08 I. Abstract In this lab, the preparation of a TPP cobalt complex was performed within a two step synthesis. To do so, benzaldehyde was condensed with pyrrole in boiling propanoic acid followed by the further addition of cobalt(II) acetate in a boiling solvent/5,10,15,20-tetraphenylporphin (TPP) mixture. The percent yield and λ max from the first step proved to be 1.78 % and 516.04 nm respectively. The percent yield and λ max from the second step proved to be 29.48 % and 556.38 nm respectively.
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II. Introduction Both present within the human body, hemoglobin and myoglobin function as critical porphyrin (nitrogen containing) components within the human body myoglobin, located within muscles, stores and releases oxygen when necessary; hemoglobin, located within red blood cells, is responsible for gas exchange. 1 The ability of both myoglobin and hemoglobin to bind to oxygen is largely due to a non- protein heme unit. Composed of four linked pyrrole rings, thus optically active, the heme unit contains
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Chem 243b - Heme Analog - 5B: Macrocyclic Synthesis (Heme...

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