Biol223_Smith_15_2005-2006Fall_Final

Biol223_Smith_15_2005-2006Fall_Final -...

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Biol223_Smith_2005-2006_FINAL 23 January 2006 PAGE 1 of 8 Biology 223 Fall 2005-2006 FINAL, 23 January 2006 EXAM COPY # No notes, no calculators, no phones. Write your name and student ID number at the top of this page. I prefer ink. Write your answer where indicated if possible, write on the back if needed. Write legibly and succinctly, using proper terminology. If I cannot read or understand your answer, you may receive no credit. Show your work and justify your conclusions, partial credit may be awarded. State any important assumptions and indicate ambiguity. Negative points may be assigned to unjustified, frivolous, and grossly incorrect answers. 100 points possible each section Section I Russell chapters 1, 2, 3, 4, 5, 6, 7, 8 Section II Russell chapters 8 (a little bit), 9, 10, 11, 12, 15, 16, 18 Section III Russell chapters 19, 20, 22 Note points per question and spend your effort accordingly! codon chart Second base I II III
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Biol223_Smith_2005-2006_FINAL 23 January 2006 PAGE 2 of 8 Section I Question 1 for 10 points The following four heterocycles are the bases found in normal DNA. a) Indicate their single letter code below each structure. b) On each heterocycle, draw an arrow to the heavy atom by which it is connected to deoxyribose. c) Circle those heavy atoms whose electron lone pairs accept hydrogen bonds in B-form DNA. N N NH N NH 2 N NH NH N NH 2 O NH NH O O C H 3 N NH NH 2 O Question 2 for 10 points The smallest sequenced genome, that of the eubacterium Mycoplasma genitalium, is only 0.58 Mb, while that of the eukaryotic Drosophila melanogaster is 180 Mb (haploid). If a replication fork progresses 100,000 bp per minute: a) Approximately how long would it take to replicate the genome of Mycoplasma genitalium (just set up the math)? b) Explain how the S phase of Drosophila melanogaster can be as short as 1 hour. Question 3 for 10 points Glutathione (GSH) is important for a number of biological functions. Two distinguishable inherited disorders are caused by mutations in glutathione synthetase (GSS). The severe form is characterized by massive excretion of 5- oxoproline (a derivative of a precursor to GSH), acidosis, anemia, and central nervous system damage. The mild form is characterized solely by anemia. The characterization of GSS activity and the GSS protein in two affected patients, each with normal parents, is given below. patient 1:
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Biol223_Smith_15_2005-2006Fall_Final -...

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