3_Patterns of Inheritance_Chromosomes

3_Patterns of Inheritance_Chromosomes - Inheritance of...

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1 Inheritance of Chromosomes and DNA • Chapter 15 2 5’ end 3’ end 5’ end 3’ end Space-filling model Partial chemical structure Hydrogen bond Key features of DNA structure 0.34 nm 3.4 nm 1 nm Jumping forward a bit: DNA is the stuff of life… 3 Rosalind Franklin Watson and Crick used the X-ray images to deduce the double helix Franklin and Wilkins made X-ray diffraction images of DNA 4 OK…so… Mendel’s “hereditary factors” are located on chromosomes
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5 Overview: Locating Genes Along Chromosomes • Mendel’s “hereditary factors” were genes, though this wasn’t known at the time • We now know that genes are located in specific loci (positions) on chromosomes Chromosomes undergo segregation and independent assortment (Mitosis and meiosis were first described in the late 1800s) • The behavior of chromosomes during meiosis was said to account for Mendel’s laws of segregation and independent assortment 6 Thomas Hunt Morgan’s fruit fly experiments provided first strong evidence that genes are on chromosomes and chromosomes are the location of Mendel’s heritable factors 7 Why fruit flies? •E a s y t o r e a r i n l a b • Short generation time (~10d) • Abundant offspring (100s per mating) • Only 4 pairs of chromosomes • Numerous mutation stocks available Drosophila 8 Correlating Behavior of a Gene’s Alleles with Behavior of a Chromosome Pair • In one experiment, Morgan mated male flies with white eyes (mutant) with female flies with red eyes (wild
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Observation P Generation F 1 Generation F 2 Generation P Generation F 1 Generation eggs Sperm
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This note was uploaded on 02/23/2010 for the course BISC 120Lg taught by Professor 11:00-01:50pm during the Fall '06 term at USC.

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3_Patterns of Inheritance_Chromosomes - Inheritance of...

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