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Fall+2007+Final - mm BMERIWWCW “ME“ FIRM Name UMIDii...

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Unformatted text preview: mm- BMERIWWCW “ME“!!! FIRM Name UMIDii Constants and units: h: 1.381-10'” J K" N, =6.022-10” mor' Ram‘s 8.314] K" mol" l N = 1 kg m s" 11 =1kgm‘ s" NOTE:’I'hroughouttheenm,makum-eyougetall themrightlm Keep at least 3 alanine-n! digits (he, use for enmple 1331-10-9 J K" for alculationsnnd not 1.38-10'”JK'!1!) Usethehochldeoflhepogeenndadditiomlpogenifyonneedmorespuce. 1) IA) Would you expect the melting temperauue T... of double stranded DNA in a buffer with neutral pH to be lower. equal. or higher if the concentration of ions in the aqueous DNA solution would be increased significantly (4?)? ll!) Explain your answer (8?)? pagelof4 2)AnionchannelpmteinJet’scallitl’,isinvolvedintheactivationofhumanimmune cells. One exploratory treatment for autoimmune diseases. which is currently undergoing clinicalnialsttoadministeramolecule, let’scall itB. thatcan blockionchannelsPin order to attenuate (slow down) the activation of autoreactive immune cells. Let’s assume that molecule B is injected into the blood stream of patients. Let’s also assume that all the immune cells that are relevant in thi: context would circulate in the blood stream and that these cells display an average number of 2.000 of then P ion channels on their surface. let‘salsousumethattheconcentrationoftheseimmunecells is l.000 cells/ml. 2A) Given that the affinity constant (Le. the equilibrium constant) for the binding interaction between bloclner B and ion channel protein P is K- 8.3‘10' M". calculate what initial concentration of B. Le, [1310. has to be administered (i.e.. reached/givenladded)tothebloodofaperson inordertooccupym oftheionchannels P with blocker B once the eqnilibrlnm ofthe binding reaction is reached (12?). 23) Assumean avengeblood volumeot'éLandaswmeamolecularweightofthebloekerB of 500 ymol. How many milligrams of drug will have to be injected in the blood stream (41’)? 2C) Given the value of the equilibrium constant K above. what is the value of 46° (in U/mol) for this binding reaction at body W (61')? page2of4 3)Afieah,tegularalkalinebauery(eg.anAAAbatuy)defiversavolugeof1.5m 1.6 V. In such a battery the following two half-reactions are relevant: Mn02+2H20+2e'-Mn(0ll)2+20fl': £9=+o.1ov Zn(OH)2+2e' —»2n+2otr; £°=-1.2sv 3A) Calculate the standard potential (difference) of a such an alkaline battery (4?). 33) Which of these two half-reactions will occur at the pluspole. which the minuspole (2P). 3C)Whataretheacmalreacfions(includingtheirditeetion)ateachpolewhenthis batteryisusedasabattery(4P)? 3D)Whatiatheovetallteactionthatoocurswhenthis baneryisusedasabaneryal’)? 3E)Whatcouldbetheteasonthattheactualvoltageof an alkaline battery is different from the standard potential (explain based on activities of the elecmoactive species) (8P)? 4) Assumeyousmdyabindinginteraction betweenapmteinandaligandinwaterand you findoutthatthis interactionissttongerat37degteesCelsinsthanatZSdegrees Celsius. You also find out that the change in enthalpy. 4H. for this binding reaction is exactlythesameatthesetwotemperatmes. 4A)Whatdotheaeobservationstellyou about the change in entropy 48 for this binding reaction (41’)? 4!!) Explain how your answer in A) can be understood on a molecular level (i.e.. talk about the entropy change of all molecules that are involved) (10?). page3of4 5) Explain why ice skaters can move with such extremely low friction ovet the ice. You havetomaketwo impottantpointsthatacttogetherin iceskatingforacompleme answer (10?). 6) 6A) Explain. form a thermodynamic point of View. why spxcading salt on streets melts snow and ice (6?). 63) Make a diagram to suppon your thetmodyamic explanation (4P). flWhatmflnmmmpdpmsesmmegenmdmofAWinthenfimehondiaofthe cells inourbody? 7A) Which molecule is oxidized inside d1:mhochondria(3P)?7B) Whatisooupledtothisoxidation (3P)? 7C)Whntpmvides theenergyforthc formation of ATP (SP)? 70) What generate: this enetgy(3P)? pagc4of4 ...
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