03EnzymesIntro - 1 BioProcess Engineering Input to cells...

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2 BioProcess Engineering Cell function Environment Environment Production Drug disc Tissue Eng Genome Input to cells Input to cells Cellular program Cellular program Understand program Manipulate program Control Input
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3 We’ve learned of classification of cells and structure of cells but… How does cell construct itself? How do cells generate energy? How does it perform complex functions such as coagulate blood when you are bleeding? How can it be made to produce useful products (penicillin, growth factors, etc)
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4 Some of the chemical reactions occuring in a cell (500 chemicals, ~5%)
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5 What is an ENZYME? Function Structure Types Applications Mechanism of catalysis Transition State Theory
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6 Activation Barrier Need to lower activation barrier – Enzyme/Catalyst
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7 Enzymes - Definition Biological catalysts Primarily proteins Highly specific May require cofactors Sensitive to environment (temperature, pH, etc.) Can function in vitro
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8 Other Definitions Catalyst - A substance that increases the rate of a reaction without modifying the overall standard Gibbs-energy change in the reaction. The catalyst does not appear in the stoichiometric expression of the complete reaction.
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9 5.4.2.5 Phosphoglucomutase a-D-glucose 1-phosphate a-D-glucose 6-phosphate
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10 Glucose
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11 Synthesis – Condensation OK, reactions where product has lower energy than substrate is understandable. But how about when product seems to have higher energy than substrate?
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03EnzymesIntro - 1 BioProcess Engineering Input to cells...

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