GeneExpressionEukary - Eukaryotic Gene Expression and...

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1 Eukaryotic Gene Expression and Genomic Organization I. Overview A. Gene expression for eukaryotes is more complex than for prokaryotes, because: 1. have larger genomes with much non-coding DNA a. requiring DNA to be more organized, and forcing related genes to be farther apart 2. require cell specialization a.ka. differentiation B. Each eukaryotic cell expresses a small fraction of its entire genome [cellular differentiation] 1. cellular differentiation must be regulated for life 2. transcription factors and enhancers are critical 3. incorrect gene action has serious implications
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2 II. Structure of Chromosomes A. Complete genomes are always double-stranded DNA 1. Compared to Eukaryotic DNA, Prokaryotic DNA is: a. much shorter b. complexed with only a few protein molecules c. less structured and folded 2. Eukaryotic DNA is: a. complexed with a large amount of histone protein to form chromatin b. highly extended during interphase* c. condensed and folded into thick chromosomes during mitosis
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This note was uploaded on 02/23/2010 for the course ENGLISH 1011 taught by Professor Thompson during the Spring '07 term at University of California, Berkeley.

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GeneExpressionEukary - Eukaryotic Gene Expression and...

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