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Unformatted text preview: Fall Clinical 2009 Patricia K Farris, M.D. Consultant Medicis Dermik Neutrogena Whats New? 1981 1983 2003 2008 Xyderm I Xyderm II Cosmoderm I, II Evolence Xyplast Cosmoplast Evolence Breeze Pig tendon 35mg/ml type I collagen D-ribose cross-linking Enzymatic digestion of antigen portions Enzymatic digestion of antigen portions No skin testing Multicenter trial, blinded N=149 Split face (NLFs) Evolence vs Restylane Evolence vs Restylane Filled to optimal cosmetic result (OCR) Could receive touch up in 2 weeks Follow up 3 month intervals after OCR up to 12 months Narins et al, Dermatol Surg 2007;33(suppl 2): S213-221 Demonstrated non-inferiority at 6 months ELISA results no antibodies to porcine collagen of clinical significant AEs injection site reactions Further studies published showed persistency of Evolence for 12 months Narins et al, Dermatol Surg 2007;33(suppl 2): S213-221 Narins et al, Dermatol Surg 2008;34:S31-S39...
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