10.17.09 ~ 9.40 ~ Weiss ~ Fat Removal for the Clinician

10.17.09 ~ 9.40 ~ - Robert A Weiss MD Associate Prof of Dermatology Johns Hopkins Director Maryland Laser Skin Vein Institute Baltimore MD Body

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10/10/2009 1 Robert A. Weiss, MD Associate Prof of Dermatology, Johns Hopkins Director Baltimore, MD Body Shaping Market What Cellulite Isn’t: Fat Alone
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10/10/2009 2 Septae in Cellulitic Fat Deep vascular Plexus in dermis Primary Microlobule Vein Artery Fibrous Septum Secondary Microlobule { Fat and Cellulite Rx Non-invasive devices cellulite Bio-mechanical + laser - Tri -Active, Smoothshapes + RF Velasmooth Cryolipolysis Zeltiq Radiofrequency - Thermage Ultrasound - Ultrashape, Liposonix Invasive delivered via fiber optics after puncture 1064nm 1320nm 924nm
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10/10/2009 3 Combined Energy Laser (915nm) and LED Light (650nm) 650nm increases cell membrane permeability while 915nm liquefies fat. Both contribute to collagen regeneration and improve circulation. PreTX 3 MO FU Cryolipolysis What is Cryolipolysis? Non-invasive cooling of fat cells to induce lipolysis without damage to other tissue types Precise energy extraction (cold) optimized to injure only fat cells Precise cooling enables safety and only affects fat cells while sparing skin, nerves, muscle; i.e., selective cryolipolysis Fat cell death due to apoptosis after cold exposure Inflammatory response to initial cold injury in fat layer Results in gradual release of lipids The Zeltiq non-invasive cooling device is not cleared for use by FDA for lipolysis; it is limited by United States law to investigational use.
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10/10/2009 4 Ultrasound Pre-treatment and 3-month post-treatment images of subcutaneous fat showed 0.7 cm or >40% decrease in thickness of fat layer occurred over a 90-day period Gross Pathology Gross pathology from the same treatment site showed superficial fat layer at the center of treatment site reduced 1 cm or 50% at 90 days post-treatment compared to untreated region Skin Fat layer Fascia Pre-treatment 3 months post-treatment 1.6 cm 0.9 cm 1.2 cm 1.3 cm Consistent Effect of Cryolipolysis 1 1 Published as a poster at ASDS 2008 – “Cryolipolysis for Noninvasive Fat Cel Destruction: Initial Results from a Pig Model”, Brian Zelickson, et al The Zeltiq non-invasive cooling device is not cleared for use by FDA for lipolysis; it is limited by United States law to investigational use. Day 3
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This note was uploaded on 02/23/2010 for the course ENGLISH 1011 taught by Professor Thompson during the Spring '07 term at University of California, Berkeley.

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10.17.09 ~ 9.40 ~ - Robert A Weiss MD Associate Prof of Dermatology Johns Hopkins Director Maryland Laser Skin Vein Institute Baltimore MD Body

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