10.17.09 ~ 12.10 ~ Farris ~ Natural Ingredients and their Applications in Dermatology

10.17.09 ~ 12.10 ~ Farris ~ Natural Ingredients and their Applications in Dermatology

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Unformatted text preview: NATURAL INGREDIENTS IN SKIN CARE PRODUCTS Patricia K Farris, M.D. FallClinical 2009 Disclosure Beiersdorf Galderma Guthy ‐ Renker La Roche Posay Neutrogena Steifel Unilever Source of Active Ingredients IS NATURAL BETTER THAN SYNTHETIC? Synthetic Cosmeceutical Actives Retinoids (tretinoin, tazarotene) Synthetic anti ‐ oxidants idebenone Peptides Pal ‐ KTTKS (Matrixyl) Matrixyl 3000 (GHK,GQPR) Argeriline Natural Actives Preferred by consumers Viewed as safe and effective Origin in folklore and Chinese medicine Plentiful Less scrutiny by regulatory agencies Challenges of Natural Actives Screen botanicals GrowingConditions Location Harvesting conditions Processing of the plant Processing plant Extract Oil Powder Granules Grains Liquid Evaluation of Cosmeceutical Actives Cosmeceutical Active Epidermal Dermal Equivalent Biomarkers Procollagen 1 Hyaluronic acid MMP 1,2,3,7,8,9,12 Fibronectin Keratin 1,6,10,11 Involucrin IL1 ,IL6,IL8,IL1ra Biologic Activity CharacterizeGene expression Antioxidant, anti ‐ inflammatory, collagen production, MMP’s, NFK ‐ B etc Allows manufacturer to categorize active Allows manufacturer to categorize active In vitro classification Natural Ingredients In Skin Care VitaminC,A, E Niacinamide Green tea Kinetin Silibinin CoffeeBerry Grape seed extract Pycnogenol Lavender Chamomile Silibinin Olive oil Soy Oatmeal Pomegranate Silymarin...
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This note was uploaded on 02/23/2010 for the course ENGLISH 1011 taught by Professor Thompson during the Spring '07 term at Berkeley.

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10.17.09 ~ 12.10 ~ Farris ~ Natural Ingredients and their Applications in Dermatology

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