2.2.10 HW 2

# 2.2.10 HW 2 - Does Vitamin C Benefit Health Structure of Vitamin C o Micronutrient Ascor

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Biostatistics Bios600.001 Second Semester 2009-2010 Homework #2: Probability Models and their Applications in Public Health Reminder: Save your SAS output files for each problem so that you might refer back to them in the future and could show your work (e.g. for an unexpected audit!). Due Date 9:30 am in class on Feb 2, 2009 Problem 1. Vitamin A Supplementation to Prevent Children’s Mortality in Nepal Section 1: Probability, Binomial and Poisson Models Learning Objectives: Students who successfully master this section will be able to: 1) use the concepts of probability to describe the effect of Vitamin A on mortality; 2) define and apply the term “effect modification” or equivalently “interaction” in a randomized trial; 3) use the binomial distribution and the Poisson approximation to the binomial to calculate probabilities of certain events. Scientific Background: Xerophthalmia, due to vitamin A deficiency, was long known to be a leading cause of childhood blindness in the developing world. However, in the late 1970s, Dr. Alfred Sommer and his Indonesian colleagues observed that children with mild, non-blinding xerophthalmia (those having night blindness or Bitot’s spots, which are dry patches that form on the conjunctiva) were at a 4-fold higher risk of dying than children with normal eyes.

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## This note was uploaded on 02/24/2010 for the course BIOS 600 taught by Professor Staff during the Spring '08 term at UNC.

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2.2.10 HW 2 - Does Vitamin C Benefit Health Structure of Vitamin C o Micronutrient Ascor

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