CH_4 - Cell Membrane Structure and Function Chapter 4...

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Cell Membrane Structure and Function Chapter 4
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Cystic Fibrosis Caused by defective protein channel (CFTR) in epithelial cells Not enough Cl- and water cross membranes Thick mucus clogs airways and ducts throughout body Usually fatal by age 30
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Main component of cell membranes Gives membrane its fluid properties Fatty acid tails sandwiched between hydrophilic heads Lipid Bilayer lipid bilayer fluid fluid
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Membrane Function Selectively isolates inside of the cell from the outside Regulates exchange of substances in & out of the cell Facilitates communication with other cells
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Fluid Mosaic Model Membrane is a mosaic of Phospholipids Glycolipids Sterols Proteins Most phospholipids and some proteins can drift through membrane
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Membrane Proteins active transporters receptor protein adhesion protein communication protein passive transporter recognition protein
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Membrane Experiments Split membranes reveal embedded proteins
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Membrane Proteins Transport proteins: regulate movement through membrane Channel proteins Carrier proteins Receptor proteins: trigger cellular response when specific molecules attach Recognition proteins: ID tags and attachment sites Glycoproteins
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Hybrid human-mouse cell shows some proteins drift within membrane Membrane Experiments human cell mouse cell hybrid cell
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CH_4 - Cell Membrane Structure and Function Chapter 4...

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