Lec 10 - + GAP phosphorylase Fig 15-27 Priming by casein...

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Metabolic Biochemistry BIBC102 Lecture 10 January 31, 2007
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synthase Phosphofructokinase (PFK-1) Fructose-1,6-bis phosphatase GLYCOGEN UDP-Glu Glu-1P Glu-6P Fru-6P Fru-1,6 bis P DHAP + GAP phosphorylase
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phosphorylase Phosphofructokinase (PFK-1) Fructose-1,6-bis phosphatase GLYCOGEN UDP-Glu Glu-1P Glu-6P Fru-6P Fru-1,6 bis P DHAP + GAP synthase
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Fig 15-14 PROTEIN PHOSPHORYLATION A MECHANISM TO CONTROL ACTIVITY
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Covalent modifications Ligand-induced conformational changes most active least active
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Fig 15-24 b a
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Fig 15-26 GLUCOSE IS A LIGAND ACTING AS A NEGATIVE MODULATOR
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A SIGNAL TRANSDUCTION PATHWAY
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ATP cAMP adenyl cyclase phosphodiesterase AMP ADP cAMP is a “second messenger” in cells
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LNC 12-15 cAMP-dependent Protein Kinase
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GTP cGMP guanyl cyclase phosphodiesterase GMP LNC p. 434 cGMP is another “second messenger” in cells
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hormone Glycogen ==> Glu-1-P
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Fig 15-25 muscle liver
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synthase Phosphofructokinase (PFK-1) Fructose-1,6-bis phosphatase GLYCOGEN UDP-Glu Glu-1P Glu-6P Fru-6P Fru-1,6 bis P DHAP
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Unformatted text preview: + GAP phosphorylase Fig 15-27 Priming by casein kinase II PROTEIN PHOSPHATASE Insulin keeps GSK3 inactive GLYCOGEN SYNTHASE KINASE 3 Fig 15-29 S T U V W HORMONE A B C D E F M N O P Q R E6 E5 E1 E2 E3 E4 Three pathways controlled by a single hormone A signal transduction pathway LNC Chapter 16 The Citric Acid Cycle Krebs Cycle TCA Cycle From G. Perkins, C. Renken, M.E. Martone, S.J. Young, M. Ellisman, and T. Frey Outer membrane Inner membrane Intermembrane space Matrix Pyruvate dehydrogenase as seen by electronmicroscopy E. coli enzyme: Mass > 4.5x10 + 2 E 1 E 3 E 2 LNC 16.3 Coenzyme A- required for decarboxylation reactions LNC 16.14 Lipoamide LNC Fig. 13-18 FAD/FMN FADH 2 /FMNH 2 Fig. 16.6 Fig. 16.6 Figure from previous edition of LNC Pyruvate dehydrogenase animation End of lecture 8 February 6, 2003 2 ADP ATP AMP + K = 0.44 Adenylate kinase...
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This note was uploaded on 02/25/2010 for the course BIBC na taught by Professor Schfler during the Spring '10 term at UCSD.

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Lec 10 - + GAP phosphorylase Fig 15-27 Priming by casein...

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