LECTURE 1 - Intro to Biochemistry Goal: To understand the...

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Intro to Biochemistry Goal: To understand the chemistry of life Motivations: 1. Acidosis 2. Alzheimer’s 3. Blood substitutes 4. HIV drugs 5. More other drugs 5. Diabetes 6. Cancer Methods: learn lots of new words learn some nitty-gritty biochemistry
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Biochemistry - Rules of the Class 1. I will provide my overheads as pdfs (on CULearn) 2. You will need to add notes. (Not all information is on the overheads.) 3. I expect you to read the book; it is good; use the Learning Objectives! - Pratt and Cornely: Essential Biochemistry 4. I will suggest problems from the book corresponding to each chapter. The answers are in the back of the book. I highly recommend you do the problems and self-grade. 5. Grading: 4 midterms (50 pts each); every Monday from 9:15 to 10:00 one cumulative Fnal (100 pts); class average = ~B-/C+ boundary
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Biochemistry - Help I will be doing review questions during class time: bring your clickers to “play” Primary ofFce hours are: Tues 11 – 12; Thurs 11 - 12 in Christol Chem 357 My e-mail is: jrudolph@colorado.edu
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Background Material Biological molecules Amino acids Carbohydrates (sugars) Nucleotides Lipids Thermodynamics and energy Entropy Enthalpy Water H-bonds Hydrophobicity pH and pKa DNA, RNA, and the central dogma
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Biological Molecules - amino acids Amino acids pp 4 - 11 R generic form SpeciFc example: alanine Central core = identical R groups vary in chemical identity, charge, hydrophobicity, etc.
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Biological Molecules - amino acids Other representations of alanine pp 4 - 11 Ball-and-stick Space-Flling
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LECTURE 1 - Intro to Biochemistry Goal: To understand the...

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