LECTURE 6 - Lipids and membranes - overview Lipids...

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Lipids and membranes - overview p 232 - 259 Lipids -saturated vs. unsaturated -cholesterol -fat soluble vitamins -triacylglycerols vs. glycerophospholipids Bilayers Membrane proteins -integral, peripheral, and lipid-linked Membrane transport -membrane potential -ion channels -glucose transporter -Na + K + transporter Endocytosis
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Lipids - saturated p 232 - 259
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Lipids - unsaturated p 232 - 259
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Lipids - unsaturated p 232 - 259 Cis vs. trans: Most natural unsaturated lipids are mostly cis. Cis does not pack as well as trans or saturated. Melting point of cis > melting point of saturated
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Lipids - partially hydrogenated vegetable oil Saturated fatty acids (meat lard dairy) = bad (raise levels of LDL cholesterol) Unsaturated fatty acids (vegetable oils) = good (may even lower LDL cholesterol) However, unsaturated fatty acids become rancid and are liquid Therefore, partially hydrogenate (chemically reduce) = more stable and more useable for baking However, partial hydrogenation yields trans fatty acids = increase total cholesterol and LDL, and decrease good cholesterol HDL (oops)
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Lipids - cholesterol p 232 - 259 Cholesterol modulates membrane fuidity
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Lipids - cholesterol
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Lipids - fat soluble vitamin A p 232 - 259 Vitamin A: -visual perception (cis --> trans isomerization) -defciency = night blindness -cellular diFFerentiation (excess is toxic: birth deFects) -immune response
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Lipids - fat soluble vitamin D p 232 - 259 Vitamin D: -”made” by sunlight -calcium homeostasis (bone formation) -deFciency = rickets (consider skin color, lactose intolerance) O H sunlight O H 7-dehydrocholesterol previtamin D 3 O H O H 6-s-trans Vitamin D 3 6-s-cis Vitamin D 3
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Lipids - fat soluble vitamin E p 232 - 259 Vitamin E: -keeps polyunsaturated fats from oxidizing -the fat-soluble vitamin C -deFciencies seen only in extremely obese
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Lipids - fat soluble vitamin K p 232 - 259 Vitamin K: -K is for koagulation -required for Glu --> Gla modiFcation in serine proteases of blood clotting cascade -deFciency = hemorrhagic disease -warfarin = blood thinner
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Lipids - triacylglycerols = storage lipids p 232 - 259
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Lipids - glycerophospholipids = membrane lipids p 232 - 259
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Membranes p 232 - 259
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This note was uploaded on 02/25/2010 for the course CHEM 4611 at Colorado.

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LECTURE 6 - Lipids and membranes - overview Lipids...

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