Review5 - Renin
is
most
related
to
 A.  B. ...

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Unformatted text preview: Renin
is
most
related
to
 A.  B.  C.  D.  Trypsin
 Sub7lisin
 Pepsin
 Chymotrypsin
 Vitamin
K
deficiency
is
associated
with
 A.  B.  C.  D.  AIDS
 Bleeding
 High
blood
pressure
 Alzheimers
 In
a
high‐throughput
screen
(HTS),
you
test
the
 ac7vity
of
your
enzyme
with
many
different
 A.  B.  C.  D.  E.  Concentra7ons
of
a
substrate
 Concentra7ons
of
an
inhibitor
 Inhibitors
at
one
concentra7on
 Substrates
at
one
concentra7on
 Enzyme
concentra7ons
 HIV
protease
is
most
related
to
 A.  B.  C.  D.  Trypsin
 Sub7lisin
 Pepsin
 Chymotrypsin
 One
reason
ACE
inhibitors
are
not
as
effec7ve
as
they
 could
be
is
that
 A.  Angiotensin
I
can
interact
with
the
angiotensin
II
 receptor
 B.  Angiotensin
I
spontaneously
degrades
to
angiotensin
 II
 C.  Angiotensin
I
is
converted
to
angiotensin
II
by
other
 proteases
 D.  Renin
can
interact
with
the
angiotensin
II
receptor
 The
affinity
between
thrombin
and
phospholipid
head
 groups
is
mediated
by
 A.  B.  C.  D.  E.  Carboxylated
glutamate
residues
 Zn2+

ions
 Ca2+
ions
 A
and
B
 A
and
C
 HIV
protease
has
a

 A.  High
substrate
specificity
 B.  Low
substrate
specificity
 Lipinski’s
rules
are
used
to
 A.  B.  C.  D.  Develop
a
high
throughput
screen
(HTS)
 Evaluate
the
potency
of
hits
from
a
HTS
 Evaluate
the
chemical
structures
of
hits
from
a
HTS
 Make
a
hit
from
a
HTS
less
suscep7ble
to
degrada7on
 HIV
protease
 A.  B.  C.  D.  E.  Has
a
Ser‐His‐Asp
cataly7c
triad
 Uses
nucleophilic
catalysis
 Uses
intrinsic
binding
energy
 B
and
C
 A,
B
and
C
 ACE
inhibi7on
is
a
treatment
for
 A.  B.  C.  D.  E.  Alzheimers
 Bleeding
disorders
 High
blood
pressure
 Diabetes
 Cancer
 Counterscreens
are
used
to
test
 A.  Potency
of
a
lead
molecule
 B.  Selec7vity
of
a
lead
molecule
 C.  Specificity
of
a
substrate
 Gla
residues
are
 A.  B.  C.  D.  Modified
nucleo7des
 Modified
bases
 Modified
amino
acids
 Not
a
real
thing
 Heparin
is
used
to
 A.  Promote
blood
coagula7on
 B.  Prevent
blood
coagula7on
 C.  A
or
B;
depends
on
the
situa7on
 Factor
IX
in
the
blood
clo]ng
cascade
is
most
related
 to
 A.  B.  C.  D.  Trypsin
 HIV
protease
 Pepsin
 Carbonic
anhydrase
 Pro‐drugs
are
made
because
they
 A.  B.  C.  D.  E.  Bind
more
potently
to
their
enzyme
target
 Are
more
soluble
than
the
actual
drug
 Are
converted
to
the
actual
drug
inside
the
pa7ent
 A
and
B
 B
and
C
 Vitamin
K
is
required
to
 A.  Promote
blood
coagula7on
 B.  Prevent
blood
coagula7on
 C.  A
or
B;
depends
on
the
situa7on
 Heparin
is
to
the
_______
as
BPG
is
to
the
____‐state
 of
hemoglobin

 A.  B.  C.  D.  thrombin/an7‐thrombin
complex,
R
 thrombin/an7‐thrombin
complex,
T
 thrombin,
R
 thrombin,
T
 Gla
residues
have
_____
charge
than
Glu
residues
 A.  one
more
posi7ve
 B.  one
more
nega7ve
 C.  the
same
 BACE
protease
is
most
related
to
 A.  B.  C.  D.  Trypsin
 Sub7lisin
 Pepsin
 Chymotrypsin
 The
reason
renin
is
used
as
a
counterscreen
for
BACE
 inhibitors
is
because
it
is
a
 A.  Zn2+‐dependent
protease
 B.  Aspar7c
acid
protease
 C.  Serine
protease
 Under
kcat/Km
condi7ons,
the
reason
the
pep7de
 VKLAV
is
cleaved
much
slower
by
chymotrypsin
than
 VKLFV
is
 A.  Lack
of
substrate
binding
 B.  Lack
of
intrinsic
binding
energy
 C.  Both
A
and
B
 ...
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