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Unformatted text preview: Linkage and mapping What did Mendel say when asked, why did the chicken cross the road? To get a road map To see if it was dominant In the test cross above what is the arrangement of the alleles? A. B. C. 2 Wildtype female Aa Bb Curly wings, orange eyes aabb X : A b a B a b a b a b A B a b a b A B a b a b a b D . A or B E. A,B, or C X X X In the test cross above what is the arrangement of the alleles? A. B. C. 2 Wildtype female Aa Bb Curly wings, orange eyes aabb X : A b a B a b a b a b A B a b a b A B a b a b a b D . A or B E. A,B, or C X X X 3 alleles in cis alleles in trans 3 alleles in cis alleles in trans 3 alleles in cis alleles in trans 17 What is the recombination frequency between curly and orange? A. 0.16 B. 0.31 C. 0.49 D. 0.50 E. 0.69 150 Wildtype Wildtype female Aa Bb Curly wings, orange eyes aabb 1,000 total progeny a = mutant version of curly A = normal version of curly b = mutant version of orange B = normal version of orange Normal dominant over mutant for both 160 curly wings, orange eyes 340 normal wings, orange eyes 350 curly wings, normal eyes X Progeny: 20 150 Wildtype 350 curly wings, normal eyes Wildtype female Cc Oo Curly wings, orange c c o o 1,000 total progeny X Progeny: A b a B a b a b a b A B a b a b a b A b a B a b Recombination Frequency (rf): # Recombinants/Total Progeny (150+160)/1000= 0.31 160 curly wings, organge eyes 340 normal wings, orange eyes What is the recombination frequency between curly and orange ? A. 0.16 B. 0.31 C. 0.49 D. 0.50 E. 0.69 a = mutant version of curly A = normal version of curly b = mutant version of orange B = normal version of orange Normal dominant over mutant for both 6 It is important to realize that crossing over produces reciprocal products A B a b X A b a b a B a b produced in equal proportions 6 It is important to realize that crossing over produces reciprocal products A B a b X A b a b a B a b produced in equal proportions Given the recombination rate predict the outcome of a cross Given RF = 16% between T and D, what is the expected frequency of gamete Td? a) 8% b) 16% c) 25% d) 50% 7 Given the recombination rate predict the outcome of a cross Given RF = 16% between T and D, what is the expected frequency of gamete Td? a) 8% b) 16% c) 25% d) 50% 7 RF is the total recombination rate for both reciprocal products so one of the two products is 1/2 the total So, now what about frequency of offspring of a cross? 8 Given the same recombinant fraction (16%) how may Warty dull pickles would you expect to see if you examined 100 progeny? A) 84 B) 42 C) 16 D) 8 So, now what about frequency of offspring of a cross? 8 Given the same recombinant fraction (16%) how may Warty dull pickles would you expect to see if you examined 100 progeny?...
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 Spring '06
 WINEY,MARK

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