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Class 18 - The central dogma and how new diversity arises...

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The central dogma and how new diversity arises
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What is the nature of “mutations”? What are the ‘natural processes’ that cause mutations? -Remember that DNA is deoxyribonucleic acid-a chemical and that it is sitting in mostly water -It is exposed to enzymes and environmental compounds that can change the fundamental nature of the DNA and/or its nucleotide components
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Causes of Mutations :
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Depurination, about 1000 times/hr in human
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Tautomeric shifts of pyrimidines
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Effects of different point mutations
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8 Please answer this question without talking to your neighbor
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9 One type of dwarfism results from the production of mutant SHR-1 protein. You look at the length of the mutant SHR-1 and the normal (wild-type) SHR-1 protein, and discover that the mutant SHR-1 protein has fewer amino acids. What do you expect to find when you examine the DNA sequence? A. nucleotides were deleted B. additional nucleotides were added C. one nucleotide was changed D. without additional information, any of the above are possible
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10 Now turn to your neighbor and talk about the question
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11 One type of dwarfism results from the production of mutant SHR-1 protein. You look at the length of the mutant SHR-1 and the normal (wild-type) SHR-1 protein, and discover that the mutant SHR-1 protein has fewer amino acids. What do you expect to find when you examine the DNA sequence? A. nucleotides were deleted B. additional nucleotides were added C. one nucleotide was changed D. without additional information, any of the above are possible
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12 Here is the answer, I will tell you how to solve it in a minute
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13
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14 A type of human dwarfism results from the production of mutant SHR-1 protein. You look at the length of the mutant SHR-1 and the normal (wild-type) SHR-1 protein, and discover that the mutant SHR-1 protein has fewer amino acids.
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