Class 37 - Espinosa

Class 37 - Espinosa - 2007 Casualties In 2007, ~1.5 million...

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2007 Casualties • In 2007, ~1.5 million new cases of cancer were diagnosed in USA. • In 2007, ~500,000 people died of cancer in USA. Cancer is the second most common cause of death after heart failure in USA, killing 1 in 4 Americans.
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Cancer Just a happy blob
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Cancers, tumors, and neoplasms. Mariah goes to the doctor and the doctor says she has breast cancer. Stephanie goes to the doctor and the doctor says she has a breast tumor. Who would you rather be, Mariah or Stephanie?
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Cancer Jargon The uncontrolled cells of a cancer can grow as a solid mass, which is called a tumor . They can also be unconnected and free-floating, as in a cancer of blood cells, i.e., leukemia If the tumor mass is contained by a capsule of connective tissue, it is called a “ benign tumor ”. This is not cancer. If the tumor cells escape and invade neighboring tissue, they are said to be “ malignant ”. This is cancer. Eventually, cancer cells could wander off and colonize distant sites: “ metastases .” The generic word “ Neoplasm ” (new growth) is used to refer to many kinds of tumors and cancers
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Neoplasms Cancers Benign Tumors Malignant Tumors Tumors Leukemias and Lymphomas (Hematopoietic Malignancies) Note: this diagram is not quantitative!
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Benign tumors are contained, malignant tumors are invasive
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The most common type of cancer is the carcinoma: a cancer originating in epithelial cells. Malignant progression requires cumulative mutations that lead to unregulated growth and invasion.
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To grow large, tumors need to do the ‘Angiogenic Switch’
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Angiogenesis is the formation of new blood vessels When a tumor ‘learns’ how to instruct The Organism to form new blood vessels, it is said that it has made the ‘Angiogenic Switch’ (bad news)
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The Metastatic Cascade The cancer cell must achieve several amazing feats in order to establish metastasis
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for cancer medicine because survival data shows that prognosis gets worse when distant metastasis has occurred. survival rate
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This note was uploaded on 02/25/2010 for the course MCDB 2150 taught by Professor Winey,mark during the Spring '06 term at Colorado.

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Class 37 - Espinosa - 2007 Casualties In 2007, ~1.5 million...

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