Class 38 - Krauter

Class 38 - Krauter - Substance dependence and antisocial...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
Substance dependence and antisocial behavior in adolescence
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The Colorado Center on Antisocial Drug Dependence MCDB/IBG/Psychiatry UCHSC
Background image of page 2
The Colorado Center on Antisocial Drug Dependence MCDB/IBG/Psychiatry UCHSC To use genetic methods to identify genes that contribute to a drug dependence phenotype.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Do Genes Play a Role in Drug Dependence?
Background image of page 4
Do Genes Play a Role in Drug Dependence? If so there must be greater similarity of the trait among close relatives than there is among more distant individuals
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Do Genes Play a Role in Drug Dependence? If so there must be greater similarity of the trait among close relatives than there is among more distant individuals Evaluate the correlation between inheritance of a particular genotype and the expression of the phenotype independent of environment
Background image of page 6
Who to study? MZ Twins - excellent for controlling for genes to examine environment Siblings (DZ, sibs) - good for controlling for environment to examine genes Adoptees - good for examining shared environments without gene sharing
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Controls and Clinical samples Clincal sample Age 13-19 Adjudicated remanded to Synergy Program Control samples Age, zip code matched community sample Colorado Twin Registry Colorado Adoption Project
Background image of page 8
What is the phenotype? Experimentation 6 drinks in your life Nicotine every day for one month Marijuana 5 or more times Dependence Tolerance, withdrawal symptoms Use more often than intended, persistent desire Social effects, work effects, psychological effects
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Example: Extent of use in control population 0 20 40 60 80 12 13 14 15 16 17 18 Percent Age in years alcohol, males alcohol, females tobacco, males tobacco, females marijuana, males marijuana, females `other', males `other', females
Background image of page 10
Extent of DEPENDENCE in control population 0 7.5 15.0 22.5 30.0 12 13 14 15 16 17 18 Percent alcohol, males alcohol, females tobacco, males tobacco, females marijuana, males marijuana, females `other', males `other', females any substance, males any substance, females
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
9 Please answer this question without talking to your neighbor
Background image of page 12
You think genes contribute to cocaine abuse, so you compare abusers of cocaine to their monozygotic twins, dizygotic twins, full siblings, and adopted siblings. If genes contribute to the tendency for cocaine abuse, then which of the
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 38

Class 38 - Krauter - Substance dependence and antisocial...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online