Class 39 - Leinwand

Class 39 - Leinwand - Heart disease in Colorado isnt so...

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Heart disease in Colorado isn’t so high and can be caused by many environmental things But ....
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Hearts enlarge by increasing cell size; not by cells dividing. HYPERTROPHY
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The heart enlarges in response to: postnatal development, exercise (physiologic) disease (pathologic)
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But,not all hypertrophy is the same.
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Cage Mounted Free-Wheel with Digital Magnetic Counter
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Rat‐TM Rat Mouse Human 0 25 50 400 500 600 Kilometers/Week Weekly Running Distances (If We Ran as Much as Mice) 575
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Approach: Exercise males and females and measure cardiac growth.
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4 months 12-15 months M F Average distance (km/day ) M F Females run more than males independently of age 4 6 * *
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C57Bl/6J M F M F HW/Time HW/Distance Normalized to distance and time, females still have greater hypertrophy than males
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There are: 1) sex differences in exercise 2) in cardiac hypertrophy in response to exercise.
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Young athletes can die suddenly from genetic heart disease.
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  • Spring '06
  • WINEY,MARK
  • Hypertrophic cardiomyopathy, cardiac hypertrophy, Hypertrophy, Familial hypertrophic cardiomyopathy, Hypertrophic Cardiomyopathy • Autosomal, • Autosomal dominant • Incidence

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