Class 41 - Sequence Analysis strategies and algorithms What...

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Sequence Analysis strategies and algorithms
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Mutations in the FGFR3 gene may cause them both to be short in stature. How do we know that humans and dogs have a similar (homologous) gene? http://tlc.discovery.com/ fansites/lpbw/bios/ amy.html http://www.pups4sale.com.au/ welsh_corgi_pembroke_03a.jpg What do Amy Roloff and Corgi’s have in common?
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Defnitions Similarity vs Homology Similarity is a quantitative measure oF the relatedness oF two sequences Homology describes two sequences related to each other evolutionarily
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Use Similarity in a sentence (correctly!)
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Use Similarity in a sentence (correctly!) Sequences share 70% sequence identity
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Use Similarity in a sentence (correctly!) Sequences share 70% sequence identity Peptides have 35% conserved amino acids and 15% identical residues
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Use Similarity in a sentence (correctly!) Sequences share 70% sequence identity Peptides have 35% conserved amino acids and 15% identical residues Each sequence has a leucine zipper motif
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Use Similarity in a sentence (correctly!) Sequences share 70% sequence identity Peptides have 35% conserved amino acids and 15% identical residues Each sequence has a leucine zipper motif NOT human FGFR3 protein is similar to dog FGFR3. ... that is homology!
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Homology A state determined by similarity as well as a conclusion that they have a common ancestor Homology is bimodal - it is or is not Homology between species is orthology Homology within a species is paralogy
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Homologous genes Genes derived from the same ancestral gene(s) DNA sequences of the lacY gene are 78% identical - perfect matches
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How do you get information from raw DNA sequence data:
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This note was uploaded on 02/25/2010 for the course MCDB 2150 taught by Professor Winey,mark during the Spring '06 term at Colorado.

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Class 41 - Sequence Analysis strategies and algorithms What...

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