Lecture%207

Lecture%207 - Lecture 7 Dictyostelium discoideum...

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Lecture 7
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Dictyostelium discoideum
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Intercellular signaling Chemical signaling
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Intercellular signaling Chemical signaling Ligand( in red): concentrated concentrated dilute Receptor Km 10 -6 10 -6 10 -10-12
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Nitric Oxide and Vasodilation
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Receptors for Water Soluble and Water Insoluble Ligands
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Non-gaseous Hydrophobic Signal Molecules
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Nuclear Receptor Superfamily
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Steps in Signal Transduction 1. Recognition -- Ligand binds receptor 2. Transduction -- Receptor changes shape 3. Amplification : -- 2 nd messengers produced, AND/OR --ion concentration gradients set up 4. Activation -- enzymes and/or structural proteins are modified, AND/OR -- additional ion channels open 5. Response -- Altered gene expression, metabolism, cell movement AND/OR /or cell shape
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Three Classes of Cell Surface Receptors
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Three Classes of Cell Surface Receptors Response time ~ 1ms Response time ~ 100ms Response time ~ 100ms
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Some Ligands Ligand Molecular weight (Da) Glycine 75 Acetylcholine 146 Insulin 5,500 Somatotropin ~20,000 Follicle stimulating hormone (FSH) ~23,000
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Three Classes of Cell Surface Receptors Response time ~ 1ms Response time ~ 100ms Response time ~ 100ms
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This note was uploaded on 02/25/2010 for the course MCDB 3120 taught by Professor Poyton,ro during the Spring '08 term at Colorado.

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Lecture%207 - Lecture 7 Dictyostelium discoideum...

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