Lecture%208

Lecture%208 - Lecture 8 G-protein-Linked Receptor Ligand...

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Lecture 8
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G-protein-Linked Receptor Ligand binding site G-protein binding site
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Three Types of Pathways Associated with G-protein-linked Receptors - inositol triphosphates, diacyglygerol and Ca++ as second messengers -cyclic AMP or cyclic GMP as second messengers - ion channel gating
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Functions of Adrenaline in Preparing Mammals for Emergencies Cardiovascular system : it increases heart rate, heart output, blood pressure Blood glucose : it stimulates breakdown of liver glycogen to glucose, which is released the blood Muscle : Promotes anaerobic breakdown of glycogen in skeletal muscle
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How Does Adrenaline Stimulate Liver Cells to Breakdown Stored Glycogen? Experiment 1. Add adrenaline to intact isolated liver cells and assay enzymes that are involved in converting glycogen to glucose. Results : Glycogen phosphorylase becomes “activated”
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How does adrenaline stimulate liver cells to breakdown stored glycogen? Experiment 2.
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This note was uploaded on 02/25/2010 for the course MCDB 3120 taught by Professor Poyton,ro during the Spring '08 term at Colorado.

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Lecture%208 - Lecture 8 G-protein-Linked Receptor Ligand...

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