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Lecture%2014 - Lecture 13 Visualization of Lysosomes Some...

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Lecture 13
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Visualization of Lysosomes
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Some Enzymes of Lysosomes Lumenal proteins Membrane proteins -- H+ATPase -- Transporters
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Plant Vacuoles are Equivalent to Animal Lysosomes
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Two Questions Regarding Pathways to the Lysosome 1. How do substrates for digestion enter lysosomes? Answer : by one of 3 routes: a. endocytosis b. autophagy c. phagocytosis 2. How do acid hydrolases enter lysosomes? Answer : by one of two pathways: a. from trans Golgi network b. from endocytosis
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Three Pathways to Degradation in Lysosomes Golgi(TGN) 1. Endocytosis 2. Autophagy 3. Phagocytosis
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Receptor-Mediated Endocytosis of LDL
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Endocytic Pathway to Lysosomes
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Three Pathways to Degradation in Lysosomes Golgi(TGN) 1. Endocytosis 2. Autophagy 3. Phagocytosis
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Lysosomal Hydrolases Travel to Lysosomes From Either TGN or Endocytosis 1 2
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Transport of Lysosomal Hydrolases to Lysosomes
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Endocytic Pathway to Lysosomes
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Exocytosis The last step on secretion Involves membrane membrane fusion Requires energy and Ca ++
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Regulated and Constitutive Exocytosis
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Regulated Secretion of Insulin By Glucose
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Protein Sorting in the trans Golgi Network
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Formation of Secretory Vesicles
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Exocytosis of Secretory Vesicles
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Exocytosis of Zymogen Granules
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Exocytosis in Rat Blast Cells
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