Lecture%2015

Lecture 15 - phosphorylation(ATP synthase transporters for substrates amino acids fatty acids Intermembrane space-nucleotide di-kinases some

Info iconThis preview shows pages 1–15. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 15
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Three ‘Keys’ to Understanding Cellular Energy Conservation/Production Innermost membranes of mitochondria and chloroplasts generate electrochemical gradients. These membranes are capable of splitting H into an e - and H + , and sending them in opposite directions across the membrane. This process is driven by either light or reduced foodstuffs
Background image of page 2
Energy Generating Metabolism in Mitochondria
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fibroblast Mitochondria Phase contrast Rhodamine stained Mitochondria
Background image of page 4
A Liver Mitochondrion
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Heart Muscle Mitochondria
Background image of page 6
Flight Muscle Mitochondria
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mammalian Sperm Cell Mitochondria
Background image of page 8
Saccharomyces cerevisiae Cells Mitochondria
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mitochondrial Network: Yeast (Hoffman and Avers. 1973) (Church and Poyton. 1998.)
Background image of page 10
Mitochondrial Network: Mammalian Cells COS-7 cells (Westermann, 2002) HeLa cells (Karbowski and Joule, 2003)
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mitochondrial Compartment Functions Compartment Function Matrix -citric acid cycle, fatty acid oxidation, factors/enzymes for mitochondrial gene expression Inner membrane -respiration (electron transport chain(, oxidative
Background image of page 12
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
Background image of page 15
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: phosphorylation (ATP synthase), transporters for substrates, amino acids, fatty acids Intermembrane space-nucleotide di-kinases, some peroxidases Outer membrane- porin, transport proteins for fatty acids Mitochondrial Inner Membranes Two States of the Mitochondrial Inner Membrane Orthodox Condensed Mitochondria As We Know Them, Or do We? Functions Classical – energy production (TCA cycle and oxidative phosphorylation), amino (aerobic) amino acid metabolism, fatty acid β- oxidation, heme biosynthesis Neoclassical – apoptosis, aging, oxygen sensing, Ca ++ homeostasis Biogenesis- Mitochondria form in the absence of mtDNA- Inner mitochondrial membrane potential is required for cell viability- Mitochondrial proteome contains ~700-800 proteins encoded by nDNA ¼ of these have no known function 1/10 of these may be targeted/localized to more than one cellular compartment. Structure: Two views...
View Full Document

This note was uploaded on 02/25/2010 for the course MCDB 3120 taught by Professor Poyton,ro during the Spring '08 term at Colorado.

Page1 / 15

Lecture 15 - phosphorylation(ATP synthase transporters for substrates amino acids fatty acids Intermembrane space-nucleotide di-kinases some

This preview shows document pages 1 - 15. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online