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Lecture%2015 - phosphorylation(ATP synthase transporters...

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Lecture 15
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Three ‘Keys’ to Understanding Cellular Energy Conservation/Production Innermost membranes of mitochondria and chloroplasts generate electrochemical gradients. These membranes are capable of splitting H into an e - and H + , and sending them in opposite directions across the membrane. This process is driven by either light or reduced foodstuffs
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Energy Generating Metabolism in Mitochondria
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Fibroblast Mitochondria Phase contrast Rhodamine stained Mitochondria
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A Liver Mitochondrion
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Heart Muscle Mitochondria
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Flight Muscle Mitochondria
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Mammalian Sperm Cell Mitochondria
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Saccharomyces cerevisiae Cells Mitochondria
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Mitochondrial Network: Yeast (Hoffman and Avers. 1973) (Church and Poyton. 1998.)
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Mitochondrial Network: Mammalian Cells COS-7 cells (Westermann, 2002) HeLa cells (Karbowski and Joule, 2003)
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Mitochondrial Compartment Functions Compartment Function Matrix -citric acid cycle, fatty acid oxidation, factors/enzymes for mitochondrial gene expression Inner membrane -respiration (electron transport chain(, oxidative
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Unformatted text preview: phosphorylation (ATP synthase), transporters for substrates, amino acids, fatty acids Intermembrane space-nucleotide di-kinases, some peroxidases Outer membrane- porin, transport proteins for fatty acids Mitochondrial Inner Membranes Two States of the Mitochondrial Inner Membrane Orthodox Condensed Mitochondria As We Know Them, Or do We? Functions Classical – energy production (TCA cycle and oxidative phosphorylation), amino (aerobic) amino acid metabolism, fatty acid β- oxidation, heme biosynthesis Neoclassical – apoptosis, aging, oxygen sensing, Ca ++ homeostasis Biogenesis- Mitochondria form in the absence of mtDNA- Inner mitochondrial membrane potential is required for cell viability- Mitochondrial proteome contains ~700-800 proteins encoded by nDNA ¼ of these have no known function 1/10 of these may be targeted/localized to more than one cellular compartment. Structure: Two views...
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