Lecture%2019

Lecture%2019 - Mitochondrial DNA replication Mitochondrial...

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Lecture 19
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Drug Specificity for Organellar and Nucleo- cytosolic Genetic Systems Organelle Nucleo-cytosolic Transcription acriflavin, ethidium α -amanitin Translation chloramphenicol, erythromycin cycloheximide, emetine
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Two Genetic Systems are required for Chloroplast and Mitochondrial Biogenesis
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Key points 1.Most mitochondrial or chloroplast proteins are imported from cytosol. 2. Proteins encoded on organelle genomes co- assemble with nuclear-encoded proteins to make functional unit.
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Genes Encoded by Human and Yeast mtDNA Human Yeast Size 16,000 bp 78,000 bp Genes -- rRNA -- tRNA -- protein NADH dehydrogenase bc 1 complex cytochrome oxidase ATP synthase 2 22 6 polypeptides Cytochrome b Subunits I,II,III Subunits 6,9 2 25 -- Cytochrome b Subunits I,II,III Subunits 6,8,9
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Origin of Mitochondrial RNAs and Proteins
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Proteins Encoded on nDNA Play 4 Types of Role in Mitochondria Mitochondrial gene expression
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Unformatted text preview: Mitochondrial DNA replication Mitochondrial assembly Mitochondrial function Nuclear-Mitochondrial Cross-talk Nuclear-Mitochondrial Cross-talk Mitochondrial Genes Import Export Nuclear Genes (~850) mRNA Targeting Translation Localization [ Assembly ] Mitochondrial-Nuclear Cross-Talk Mitochondrial-Nuclear Cross-Talk Mitochondrial Genes Transduction Import Export Nuclear Genes mRNA Signaling pathways Targeting Translation Localization [ Assembly ] Proposed Evolution of Mitochondria and Chloroplasts Suggested Origin of Mitochondria by Endosymbiosis Comparison of Bacterial, Chloroplast, and Mitochondrial Electron Transport Chains Mitochondrial Reticulum Mitochondrial Genomes Vary in Size Inheritance of Mitochondrial and Nuclear Genes in Yeast...
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This note was uploaded on 02/25/2010 for the course MCDB 3120 taught by Professor Poyton,ro during the Spring '08 term at Colorado.

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Lecture%2019 - Mitochondrial DNA replication Mitochondrial...

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