icq2 - domain Translation Ribosome binds to mRNA at the...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Class 2 Exercise Answers
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
General kinds of Mechanism Regulation at each step Transcription : Transcription factors bind to DNA regulatory elements; interact with other transcription factors or interact with h h T i ’d d (f l ) il i i i h f h h each other. To stop apoptosis, you’d need to (for example) silence transcription with a factor that prevents other TFs from binding Enzymes : can methylate or de-acetylate the promoter (thus preventing transcription); or de-methylate or acetylate the promoter, thus allowing transcription. Splicing: RNA-binding proteins bind to mRNA transcript; could either block or activate splicing sites To prevent Splicing: RNA-binding proteins bind to mRNA transcript; could either block or activate splicing sites. To prevent apoptosis, you might want to produce an alternative transcript that was non-functional, or lacked a critical
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: domain Translation : Ribosome binds to mRNA at the 5’ end. Ways of regulation include prevent binding, changing the binding constant, and changing the length of time that the mRNA trancript is available (for example, factors can bind to the 3’ UTR to stabilize the mRNA and thus allow more protein to be made). Protein modifications: Enzymes can bind to protein, ubiquitinate it to target it for degradation (do this to prevent apoptosis), or also to phosphorylate the protein (activating it). Some features that make a protein specific for regulation of a particular gene: higher affinity for or ability to bind only a specific promoter region or specific transcription factor binds to a unique site on a protein binds to a specific DNA sequence...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern