Cl02ppt - MCDB 4650 Class 2 Developmental control of gene...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
MCDB 4650 Class 2 MD 6 a Developmental control of gene expression Please fill out the attitude survey by Friday night (linked to webpage) Problem solving session sign up is now available (also linked from webpage) y office hours: ednesdays 11 2:30 My office hours: Wednesdays 11-12:30 Thursdays 9-10
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Some of the things you were interested in learning: How organs develop Modes of differentiation Similarities and differences among species Basis of developmental defects and diseases Mechanisms and regulation of cell death Experimental design and interpretation Epigenetics Secrets of the universe
Background image of page 2
Learning goals for class 2 Be able to: Compare information content of different genomes from genomic data. Define differential gene expression and its relationship to differentiation. pply the concept of Apply the concept of combinatorial control to explain the regulation of gene expression during development.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
enomic information Genomic information Which of the following is the ideal way to compare the information contained in the respective genomes of two different kinds of organisms? a) Compare the complexity (number of DNA nucleotides in non- repetitive sequences) in the two genomes. b) Sequence the two genomes, count the number of putative genes based on computer analysis, etc., and compare these umbers numbers. c) Count the number of different proteins that are synthesized throughout each animal's life cycle and compare these numbers. d) Compare the non-coding regions of the genome e) A combination of several of the above: c and d for sure, but b also provides relevant information
Background image of page 4
Genome sizes in various phyla C. elegans A 8-6
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Gene: Genome relationships in five organisms Organism Size b) Estimated ene number Coding ercentage (Mb) gene number percentage E. coli 5 ~ 4,000 ~ 80% Yeast 20 ~ 5,000 ~ 50% aenorhabditis 7 ~ 19 000 ~ 20% Caenorhabditis 97 19,000 20% Drosophila 180 ~ 13,000 ~ 8% Human 3,000 ~ 30,000 ~ 1% So human development requires only ~50% more information than worm development?
Background image of page 6
In the genomes of more complex organisms, there is a much
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 33

Cl02ppt - MCDB 4650 Class 2 Developmental control of gene...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online