Cl03ppt - Class 3 A little wrap up of gene expression...

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Class 3 A little wrap up of gene xpression expression Cell-cell signaling Problem solving session locations Thursday 2-3 Porter B118 Thursday 5-6 Porter B121 Fridays 10-11, 11-12 Porter B118
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Control over RNA processing A3 9-2
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Alternative splicing of a transcript leads to different versions of the ame protein same protein
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Control over RNA processing Control over which transcripts get transported out to the cytosol A3 9-2 Sequestration of transcripts in cytosol (location within oocyte)
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mRNA degradation and translation control A3 9-2
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mRNA stability: binding regions in the 3’ UTR Example: Casein mRNA takes much longer to degrade in the presence of the hormone prolactin 5.32
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Phosphorylation, other modifications, ubiquitination, etc. A3 9-2
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Cell signaling is the foundation of development Learning Goals 1. Describe in general the process by which developmental signals are sent from one cell and received by other cells, and what happens in the ceiving cells as a result receiving cells as a result. 2. Compare and contrast the major developmental signaling pathways (RTK,TGF β , Wnt, Hedgehog). 3. Explain how a mutant component of a signaling pathway can cause a cell to become cancerous.
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During embryonic development, cells ommunicate with each other communicate with each other This allows cells to do different things depending on what signals they received Many signaling pathways have growth factors as ligands Sometimes the changes shown y g at right are accomplished through ytoplasmic cytoplasmic localization of mRNAs and proteins rather than signaling
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Three classes of receptors A3 15-14
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here are three general types of intercellular There are three general types of intercellular signaling: juxtacrine, paracrine and autocrine 1 23 Which is which?
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This note was uploaded on 02/25/2010 for the course MCDB 4650 taught by Professor Staff during the Spring '08 term at Colorado.

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Cl03ppt - Class 3 A little wrap up of gene expression...

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