Cl04ppt - MCDB 4650 Class 4 Cell fate determination and...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
MCDB 4650 Class 4: ell fate determination and commitment Cell fate, determination and commitment Learning Goals 1. Diagram the two major mechanisms of cell determination and explain their general molecular basis. 2. Distinguish (experimentally) between cell fate and cell commitment. 3. Explain what cytoplasmic maternally-contributed determinants are, and justify their importance during evelopment development. 4. Describe how the extracellular matrix (ECM) is involved in signaling.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What does it mean (molecularly) when we say that a cell is “determined” to take on a particular fate? a. It can still make a different fate if given the right signals b. It is actively translating cell-specific proteins c. It has received the signals required for its fate d. It can no longer respond to certain signals e. It has differentiated into its known fate
Background image of page 2
Signaling plays a role in the most fundamental steps of development: cell fate and determination Fate: The fate of a cell in the embryo is the cell types and tissues that it will give rise to during normal embryogenesis. Series of changes (progressive) Determination: When a cell or group of cells become determined or committed, they are irreversibly hanged at the molecular level changed at the molecular level
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Every cell in the body has the same genetic material (as proven by the feasibility of cloning) Genomic equivalence --> differential gene expression ilbert 4 10 Gilbert, 4.10 But, during development, genes are turned on or off different cells making them different from each other in different cells, making them different from each other
Background image of page 4
Two mechanisms for specifying fate Segregation symmetric segregation of a asymmetric segregation of a determinant (mRNA or protein).
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 31

Cl04ppt - MCDB 4650 Class 4 Cell fate determination and...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online