Cl10ppt - MCDB 4650 Class 10 Neural Fate and Patterning...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
MCDB 4650 Class 10 Neural Fate and Patterning
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Neuronal fate and patterning Competence--Proneural genes are activated in cells that have been appropriately determined to be neural: --bHLH transcription factors (e.g. neurogenin) Segregation (Lateral inhibition): -- otch/Delta Notch/Delta Neurulation: cell shape changes (similarities to gastrulation) Cell fate and patterning: identity along A/P and D/V axes both signaling ligands and transcription factors
Background image of page 2
We discussed positional identity along the A-P axis last time Positional identity also has to be specified for cells along the D-V axis once the neural tube is formed
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Patterning of the neural tube (spinal cord) along the Dorsal/Ventral axis D he DORSAL side of the neural tube V The DORSAL side of the neural tube differentiates into SENSORY INTERNEURONS These neurons receive information from sensory neurons (neural crest derivatives) that lie outside the CNS in the peripheral NS.
Background image of page 4
The VENTRAL side of the D spinal cord differentiates into MOTOR neurons that send axons out to activate muscles V
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The D/V identity of the spinal cord is organized by opposing morphogens BMPs from the non-neuronal ectoderm and roof plate induce dorsal fate Shh from the notochord and floor plate induce ventral fate
Background image of page 6
How can BMPs be the “dorsalizing” signal to the neural tube when BMPs acted as “ventralizing” factors for the gastrulating embryo? here must be another ligand interacting with the BMPs to produce a. There must be another ligand interacting with the BMPs to produce this different effect b. The downstream consequence of BMP signaling must be different in the cells of the neural tube than they were in the gastrula c.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/25/2010 for the course MCDB 4650 taught by Professor Staff during the Spring '08 term at Colorado.

Page1 / 23

Cl10ppt - MCDB 4650 Class 10 Neural Fate and Patterning...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online