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problemset1 - MCDB 4650 Spring 2010 Problem Set 1 Due...

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MCDB 4650 Spring 2010 Problem Set 1 Due Friday 1/22 by midnight For multiple choice questions, there may sometimes be more than one correct answer . Please choose your answers carefully. 1. (.5) The gene diagrammed is the tropomyosin gene, expressed in a wide variety of cell types. What is the mechanism most likely responsible for the differences between the transcripts in the two cell types shown? a. Alternative transcription start sites b. Alternative translational stop sites c. Alternative splicing d. Different transcription factors present in the two cells e. Differentially methylated promoters 2. (.5) Explain what is happening at a molecular level in striated muscle that allows exon 2 to not be part of the final transcript. 3. (.5) What is one possible effect on the proteins made from these two transcripts that would be due specifically to the 3’ UTRs being different? a. the carboxy-terminal ends of the two proteins will be different b. the proteins will have different functions c. the two transcripts may exist for different lengths of time before being degraded d. the two proteins may be post-translationally modified in different ways 4. (1.5) In muscle cells, transcription factor X activates transcription of gene A. In neuronal cells, the same transcription factor activates transcription of genes A and B, and in liver cells, the same transcription factor prevents transcription of genes A and B. Explain what leads to these differences in transcription of genes A and
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This note was uploaded on 02/25/2010 for the course MCDB 4650 taught by Professor Staff during the Spring '08 term at Colorado.

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problemset1 - MCDB 4650 Spring 2010 Problem Set 1 Due...

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