Bio 1A Lect 6 - Biology 1A Professor Doudna 02/01/10 8am 1...

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Lecture #6: Cellular metabolism Reading: Chapter 8, pp. 142‐150 Lecture outline: Why we need enzymes Metabolic pathways Thermodynamics Free energy IntroducHon to enzymes
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Overview: The Energy of Life The living cell is a miniature chemical factory where thousands of reacHons occur The cell extracts energy and applies energy to perform work Some organisms even convert energy to light, as in bioluminescence
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An organism’s metabolism transforms ma?er and energy, subject to the laws of thermodynamics Metabolism is the totality of an organism’s chemical reacHons Metabolism is an emergent property of life that arises from interacHons between molecules within the cell
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OrganizaEon of the Chemistry of Life into Metabolic Pathways A metabolic pathway begins with a specifc molecule and ends with a product Each step is catalyzed by a specifc enzyme Enzyme 1 Enzyme 2 Enzyme 3 D C B A Reaction 1 Reaction 3 Reaction 2 Starting molecule Product
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Catabolic pathways release energy by breaking down complex molecules into simpler compounds Cellular respiraHon, the breakdown of glucose in the presence of oxygen, is an example of a pathway of catabolism Some metabolic pathways break down molecules…
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Anabolic pathways consume energy to build complex molecules from simpler ones The synthesis of protein from amino acids is an example of anabolism BioenergeEcs is the study of how organisms manage their energy resources And some metabolic pathways create molecules
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Energy is the capacity to cause change Energy exists in various forms, some of which can perform work: Kine±c energy is energy associated with moHon Heat (thermal energy) is kineHc energy associated with random movement of atoms or molecules Poten±al energy is energy that maRer possesses because of its locaHon or structure Chemical energy is potenHal energy available for release in a chemical reacHon Energy can be converted from one form to another
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Climbing up converts the kinetic energy of muscle movement to potential energy. A diver has less potential
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This note was uploaded on 02/27/2010 for the course BIO 1A taught by Professor Schlissel during the Spring '08 term at University of California, Berkeley.

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Bio 1A Lect 6 - Biology 1A Professor Doudna 02/01/10 8am 1...

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