Phystut11 - Cardiovascular Physiology III Andrew MacDonald Click to edit Master subtitle style January 28th 2010 Quick Recap Cardiac Output =

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Click to edit Master subtitle style 2/28/10 Cardiovascular Physiology III Andrew MacDonald January 28th, 2010
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2/28/10 Quick Recap! Cardiac Output = Stroke Volume (mL) x Heart Rate (bpm) Frank-Starling Law – An increase in end diastolic volume will cause an increase in the stroke volume. So we are going to focus on how the EDV volume can be increased!
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2/28/10 Increasing EDV How can the EDV be increased? Active Exercise! 1) Muscle Pump 2) Respiratory Pump 3) Sympathetic Nervous System
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2/28/10 The Muscle Pump Contraction of skeletal muscle can compress the vasculature of the venous system causing blood to flow back to the heart. An increase in venous flow increase in venous return increase in EDV ° increase in stroke volume increase in cardiac output! Veins contain multiple “one-way” valves that serve to prevent backflow in the circulatory system!
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2/28/10 Respiratory Pump The respiratory pump helps increase venous blood flow to the heart. The pressure in the thoracic cavity decreases upon inspiration. (The expansion of the thoracic cavity causes the decrease in pressure ). As a result, lower pressure is placed on the vena cava as it passes from the abdomen (higher pressure) to the thoracic cavity (lower pressure).
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2/28/10 Sympathetic Nervous System (Increasing EDV) The sympathetic nervous system innervates nearly all tissue in the body and venous vasculature is no exception. Sympathetic activity on the smooth muscle surrounding veins will cause the smooth muscle to contract. This will squeeze the blood out of the venous system and towards the heart. Remember that… The sympathetic system also innervates cardiac muscle and is able to cause an increase in HR which increases C.O.
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2/28/10 Vascular Structure As you already know there are different classifications of vasculature in the cardiovascular system. These include Aorta Large Arteries Small Arteries Arterioles Capillaries (fenestrated or continuous) Venules Small Veins Large Veins Vena Cava (inferior & superior) Each component or class of vasculature has a slightly different structure and it is this difference in structure that determines it’s function.
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2/28/10 Basic Vascular Anatomy
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This note was uploaded on 02/27/2010 for the course PHYSIOL 2210 taught by Professor Betts during the Spring '10 term at UWO.

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Phystut11 - Cardiovascular Physiology III Andrew MacDonald Click to edit Master subtitle style January 28th 2010 Quick Recap Cardiac Output =

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