Phystut7 - The Hypothalamus Alick to MacDonald Cndrew edit...

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Click to edit Master subtitle style 2/28/10 The Hypothalamus Andrew MacDonald November 19th, 2009 [email protected]il.com
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2/28/10 Why do we EAT?! Environmental & Genetic factors both contribute to why we eat. Environmental Factors: 1) Taste & Smell 2) Cost/Reward Optimization 3) Availability 4) Clock 5) Cues & Social habits Genetic Factors: 1) Genetics 2) Epigenetics 3) Imprinted 4) Early life events
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2/28/10 Food Intake & Hypothalamus (Negative feedback control system) Arcuate Nucleus & Ventromedial Hypothalamus Leptin Fat &Leptin Lateral Hypothalamus & Paraventricular Nucleus + _ Satiety Centre Feeding Centre Fat &
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2/28/10 Leptin Interactions in the Arcuate Nucleus! + Genetic disorder where Mc4r not functional results in obesity. Lateral Hypothalamus (CART) (NPY) - + (TRH Neurons) - Orexin Neurons Food Intake Paraventricular Nucleus Adipose (Fat) Tissue
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2/28/10 Ablation (lesion) of the Arcuate/VMH hypothalamic Ablation “damages or inactivates” tissue. Remember that, The Arcuate and VMH (ventromedial hypothalamic nuclei) compose the… SATIETY CENTRE
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2/28/10 Ablation of the Lateral Hypothalamic Nuclei The lateral hypothalam ic nuclei is part of the… Control LH Lesion
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Anorexia & Obesity Both anorexia & obesity affect ones health severely Are the causes of eating disorders well characterized (worked out)? No, they are thought to arise from a combination of several factors such as, 1) Genetic 2) Neurochemical 3) Pyscho-developmental 4) Socio-cultural factors All which involve the hypothalamus!
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2/28/10 Summary: Regulation of Food Intake 1. Satiety centre – Arc-VMH. 2. Hormone leptin from fat tissue acts at satiety centre to inhibit NPY neurons (NPY neurons normally stimulate food intake) and activate POMC neurons (inhibitory for food intake). 3. Damage to satiety centre causes obesity. 4. Feeding Centre – LH-PVH (damage causes anorexia). 5. Feeding Hormone- orexin (hypocretin)-found in Lateral Hypothalamic neurons. 6. Satiety Centre reciprocally connected with Feeding Centre. 7. Eating disorders are thought to be a combination of genetic, neurochemical, psycho-developmental, and socio-
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Suprachiasmatic Nucleus!
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