Phystut5b - RenalSystem:Part2 AndrewMacDonald Nov5th,2009 Whereis65%ofthefiltrate absorbed ProximalTubule Whereis20%ofthefiltrate absorbed

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Click to edit Master subtitle style Renal System: Part 2 Andrew MacDonald Nov 5th, 2009
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Reabsorption in the Kidney Where is 65% of the filtrate  absorbed? Where is 20% of the filtrate  absorbed? Where is 14% of the filtrate  absorbed? Proximal Tubule Ascending Tubule Collecting Duct This leaves about 1% of the filtrate in  the collecting duct for excretion!
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Reabsorption  Notice that the arrows denote  where reabsorption is taking  place. Reabsorption  is the  selective movement of  substances in the filtrate  into the blood. Remember that,
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The Cells of the Tubule. n The nephron is made up of a  single layer of  epithelial  cells.  n The cells have different  properties in different areas of  the nephron n This is due to the presence of  different channels for transport. How then does reabsorption and  secretion differ along the length of  the tubule?
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Cells of the Renal Tubule Capillary  Epithelial Cell Basolateral Membrane Luminal (apical)  Membrane Lumen
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Mechanisms of Tubule  Transport n 1)Reabsorption  n 1a) Paracellular transport  -  transport of a substance  between cells of the tubule. n 1b) Transcellular transport –  transport of a substance  across the cell membrane. Remember that,  Secretion  is the  transport of  substances from  the blood back into  the tubule lumen.
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Mechanism of Tubule  Transport (2) It can be seen that  reabsorption  occurs via both the  transcellular  and  paracellular  pathways.  While,  secretion  primarily occurs via the  transcellular  pathway.
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Renal Transport Mechanisms n There are  main types of transport mechanisms that are  used in the kidney. n
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This note was uploaded on 02/27/2010 for the course PHYSIOL 2210 taught by Professor Betts during the Spring '10 term at UWO.

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Phystut5b - RenalSystem:Part2 AndrewMacDonald Nov5th,2009 Whereis65%ofthefiltrate absorbed ProximalTubule Whereis20%ofthefiltrate absorbed

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