AIDS

AIDS - AIDS Michael Roybal, M.D., M.P.H. HP 200 Fall 2006...

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1 AIDS AIDS Michael Roybal, M.D., M.P.H. HP 200 Fall 2006 October 12, 2006
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2 No. of Persons (in thousands)
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11 HIV particle and genome HIV particle and genome envelope envelope gp120 gp41 gp120 matri x matri x p17 p17 core core p24 RT RT RNA RNA MHC MHC lipid bilayer lipid bilayer
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13 1. The stage is set for activation of a helper T cell (CD4+ T Lymphocyte) when an antigen presenting cell (APC, usually a macrophage) ingests a microbe, such as a virus. The APC chops the virus up into many small proteins, called antigens, and displays these proteins on its surface. 2. The T cell becomes activated if an antigen receptor on its surface fits into one of the displayed antigens, if a CD4+ cell surface molecule attaches to the antigen complex, and if certain other molecules (B7 and CD28, at right) are able to link together.
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14 3. The activated T cell proliferates. Activated T cells also display two other molecules: Fas and Fas ligand. The above illustration details the process of antigen presentation to CD4+ T-Helper Cells (T-4 cells)
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This note was uploaded on 02/28/2010 for the course HP 200 taught by Professor Roybal during the Fall '05 term at USC.

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AIDS - AIDS Michael Roybal, M.D., M.P.H. HP 200 Fall 2006...

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