6 - PSY308 Biopsychology Neurotransmitters Overview...

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PSY308 Biopsychology Neurotransmitters
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Overview Neurotransmission steps Neurotransmitters
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Experiments of Otto Loewi Chemical Transmission
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Neurotransmitter Criterion Present in the presynaptic terminal Synthesis of the transmitter in the cell Released in response to stimulation Postsynaptic receptors for neurotransmitter to have an effect Inactivation of transmitter Synaptic mimicry Pharmacologic effect
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Steps in Neurotransmission 1. Synthesis of the NT 2. Storage of NT
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1. Release of NT : exocytosis Steps in Neurotransmission
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4. Receptor Action Steps in Neurotransmission Rosenzweig M.R. et al., Biological Psychology (2002)
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5. Inactivation of NT Steps in Neurotransmission Reuptake Enzymatic degradation Rosenzweig M.R. et al., Biological Psychology (2002) Two major ways to clear out the NT
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Drug can influence neurotransmission at all levels. Synthesis of NT
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6 - PSY308 Biopsychology Neurotransmitters Overview...

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