7 - PSY308 Biopsychology Drug actions Overview Some Basic...

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PSY308 Biopsychology Drug actions
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Some Basic Concepts and Definitions Psychoactive Drugs Tolerance Sensitization Withdrawal Syndromes Physical dependency Addiction Psychoactive drugs Classification Actions Mechanisms Overview
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Any chemical substance that alters mood or behavior as a result of alterations in the functioning of the brain Psychoactive Drugs
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Tolerance Decreased sensitivity to the effects of drug as a result of exposure
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Sensitization Increased sensitivity to the effects of drug as a result of exposure
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Common mechanisms -Increased Breakdown *“Metabolic Tolerance”, drug broken down faster - Neuronal Adaptation = MOST common *“Functional Tolerance”, brain adapts to changes and develops responses to compensate Tolerance Conditioned Drug Tolerance = based on environment (situation specific drug tolerance)
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Conditioned drug tolerance Hypothermia effects of alcohol in rats First alcohol injection 21 st alcohol injection
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Addiction (one definition) habitual drug use with adverse social and/or health effects that resists attempts to stop the drug use Physical dependency the onset of withdrawal syndromes upon removal of the drug Withdrawal syndromes Adverse physiological reaction Opposite to the initial effects of the drug
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Pleasure center Natural reward food, water, sex Self-administration e.g., Cocaine, Amphetamine, & morphine
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Self-administration into the nucleus accumbens Self-administration with the intact nucleus accumbens NO Self-administration without the nucleus accumbens
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A.
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