110709MendelianObesity

110709MendelianObesity - M endel i an obesi ty Exampl es...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Mendelian obesity Examples and illustrations of basic principals of weight regulation provided by studies of people with Mendelian forms of obesity.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Obesity is complex The heterogeneity of the disease makes it difficult to study: Different etiologies Difficult to define Many genes involved (polygenic) Different environments Different levels of gene-environment interaction
Background image of page 2
Mendelian Disease Essentially…If you inherit the mutation, you have the disease. R r R r RR Rr Rr rr Complex Disease Essentially…genotype doesn’t always predict phenotype due to complexities R r R r RR Rr Rr rr? affected Dependent on gene interactions, environment, etc.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Obesity is a Complex Disease OBESITY Genetics How many? What impact? How many people have the mutation? Environment How to measure? How to control for? How does gene interact with environment Different for every gene?
Background image of page 4
Approaches to Find Human Obesity Genes Family-based Linkage Studies Population-based Association Studies
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What accounts for the genetic determinants of common obesity? Multiple genes, gene-gene interactions, gene- environment interactions Common disease/Common variant theory common variants that confer only increased risk for the individual, but proportion of population it would affect would be high. Rare Variant theory rare monogenic variants -- many in a population.
Background image of page 6
Rare Variant theory Population risk of obesity is due to rare mutations in many genes Each gene would likely have many occurring mutations, each rare The commonness of obesity would be a sum these many rare mutations
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Common disease/Common variant theory The variant (mutation) occurs with relatively high frequency in a population
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/01/2010 for the course NPB 97952 taught by Professor ? during the Fall '09 term at UC Davis.

Page1 / 37

110709MendelianObesity - M endel i an obesi ty Exampl es...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online